Mouse cristin/r-spondin family proteins are novel ligands for the frizzled 8 and lrp6 receptors and activate β-catenin-dependent gene expression*

HIGHLIGHTS

• who: Ju-Suk Nam from the (UNIVERSITY) have published the research: Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression*, in the Journal: (JOURNAL) of May/12,/2006
• what: The authors provide evidence strongly suggesting that a multigene family of novel secreted proteins, mouse Cristin/R-spondin proteins, may work at the receptor level to activate downstream ␤-catenin-dependent gene activation and may function as a class of ligands unrelated to Wnt proteins. Fine Control of Canonical Wnt Signaling Activity-Our study . . .
  

   

  

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