Movement which add noise to the signal [ 1 – 3 ]. an alter- native approach is to incorporate pharmacokinetic models into infusion pumps which estimate propofol plasma and effect-site concentrations during target-controlled infusions (tci) [ 4 ]. despite recent development of a new pharmaco- kinetic model that include data from thousands of patients [ 5 ], errors still exceed 22% [ 6 8 ]. inappropriate dosing may cause haemodynamic instabil-

HIGHLIGHTS

• who: Anaesthesia Exhaled propofol Ion and colleagues from the CBR, Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Faculty of Medicine, Saarland University Medical Center, Saarland University, Homburg, Saar, Germany have published the article: movement which add noise to the signal [ 1 - 3 ]. An alter- native approach is to incorporate pharmacokinetic models into infusion pumps which estimate propofol plasma and effect-site concentrations during target-controlled infusions (TCI) [ 4 ]. Despite recent development of a new pharmaco- kinetic model that include data from thousands of patients [ 5 ], errors still exceed 22% [ 6 8 ]. Inappropriate . . .
  

   

  

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