Mrna cap methylation in pluripotency and differentiation

HIGHLIGHTS

  • who: Laura Grasso from the Department University of Dundee, Dow Street, Dundee , EH, UK have published the research: mRNA Cap Methylation in Pluripotency and Differentiation, in the Journal: (JOURNAL)
  • what: The authors report that regulated methylation is a feature of embryonic stem cell (ESC) Expression of methyltransferase activating subunit RAM is elevated ESCs resulting high levels of methylation and expression of a cohort of pluripotency-associated genes. The authors report that RNMT-RAM is regulated during embryonic stem_cell (ESC) differentiation and fibroblast reprogramming. RAM S36 lies in a potential recognition motif for several kinases, including . . .

     

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