Mtorc1 and ck2 coordinate ternary and eif4f complex assembly

HIGHLIGHTS

• who: Valentina Gandin from the Lady Davis Institute, SMBD JGH, McGill University, Montreal, Quebec, Canada H T , Department of Oncology, McGill University, Montreal, Quebec have published the research work: mTORC1 and CK2 coordinate ternary and eIF4F complex assembly, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 23/02/2016
• what: The authors show that mTOR suppresses translation of mRNAs activated under short-term stress wherein TC recycling is attenuated by eIF2a phosphorylation. The authors demonstrate a formerly undocumented role for CK2 in regulation of translation initiation whereby CK2 stimulates phosphorylation of eIF2b and simultaneously bolsters . . .
  

   

  

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