Mtorc1 inhibition protects human regulatory t cells from granzyme-b-induced apoptosis

HIGHLIGHTS

  • who: Siawosh K. Eskandari from the (UNIVERSITY) have published the paper: mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis, in the Journal: (JOURNAL)

SUMMARY

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ACRONYMS

LAY DEFINITIONS

  • granzyme B: A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells
  • rapamycin: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional . . .

     

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