HIGHLIGHTS
- who: Zhengping Huang from the (UNIVERSITY) have published the research work: mTORC1 links pathology in experimental models of Stillu2812s disease and macrophage activation syndrome, in the Journal: (JOURNAL) of 28/Oct/2021
- what: The authors show that mTORC1 (mechanistic target of rapamycin complex 1) underpins the pathology of Still`s disease and macrophage activation syndrome. The authors characterize the immunologic features of SD and MAS using several mouse models and complementary human studies. The authors demonstrate relevance of these findings in humans by analyzing transcriptomic datasets and tissue sections from patients with SD. The authors . . .
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