Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death

HIGHLIGHTS

• who: Geiger Jonathan D. from the University of North Dakota School of Medicine and Health Sciences, School of Medicine and Health Sciences, Grand Forks, ND, USA have published the article: Mu opioid receptor-mediated release of endolysosome iron increases levels of mitochondrial iron, reactive oxygen species, and cell death, in the Journal: (JOURNAL)
• what: The authors focused on endolysosome-resident TPCs because activation by the endogenous agonist NAADP increased the efflux of divalent cations from endolysosomes . The study demonstrates that opioids induce an MOR-mediated efflux of endolysosome Fe2+ that is sufficient to increase cytosolic . . .
  

   

  

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