Mucosal-associated invariant t cells are a profibrogenic immune cell population in the liver

HIGHLIGHTS

• who: Pushpa Hegde from the Laboratoire have published the article: Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors assessed whether MAIT_cells contribute to the pathogenesis of liver fibrosis. The authors show that MAIT_cells display proinflammatory and profibrogenic functions during chronic liver injury.
• how: In coculture experiments activated MAIT_cells enhanced the production of IL-6 and IL-8 by hepatic myofibroblasts as shown by FACS analysis and ELISA (Fig 4a b Supplementary Fig 4a) similar results were obtained . . .
  

   

  

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