Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems

HIGHLIGHTS

• who: Deepak A. Subramanian from the (UNIVERSITY) have published the Article: Mucus interaction to improve gastrointestinal retention and pharmacokinetics of orally administered nano-drug delivery systems, in the Journal: (JOURNAL)

SUMMARY

(GI) tract inhibits effective oral delivery of large drug depots (1-10 g) and macromolecular biologic drugs (e_g, peptides, proteins). Obstacles include degradation of biologic drugs, rapid GI transit time, and inefficient drug transfer from the GI tract to the bloodstream, all of which ultimately lead to poor drug bioavailability. Orally ingested materials transit through the whole GI tract in about 24 . . .

 



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