Multi-acting mitochondria-targeted platinum(iv) prodrugs of kiteplatin with -lipoic acid in the axial positions

HIGHLIGHTS

• who: Salvatore Savino et al. from the Department of Chemistry, University of Bari Aldo Moro, Via EOrabona, Bari, Italy have published the paper: Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with -Lipoic Acid in the Axial Positions, in the Journal: (JOURNAL)
• what: On this basis the authors decided to explore the conjugation of ALA (another activator of the pyruvate dehydrogenase complex like DCA) in the axial positions of a Pt(IV) derivative of kiteplatin and in this paper the authors report the synthesis, characterization, and biological activity of two kiteplatin derivatives, cis,trans . . .
  

   

  

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