HIGHLIGHTS
- who: Alex Avdeef from the in-ADME Research, First #102, New York, NY, USA have published the Article: Multi-lab intrinsic solubility measurement reproducibility in CheqSol and shake-flask methods, in the Journal: (JOURNAL) of 11/09/2019
- what: This brief commentary reasserts that the quality of the standardized CheqSol measurements is comparable to that of the ‘gold standard' saturation shake-flask measurements.
SUMMARY
This commentary considers the interlaboratory reproducibility of published aqueous intrinsic solubility data (log S0) for 124 drugs, determined both by the potentiometric CheqSol (CS) method (233 reported . . .
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