Multi-level cellular and functional annotation of single-cell transcriptomes using scpipeline

HIGHLIGHTS

• who: Nicholas Mikolajewicz from the University of Toronto, Toronto, ON, Canada have published the research work: Multi-level cellular and functional annotation of single-cell transcriptomes using scPipeline, in the Journal: (JOURNAL) of 13/04/2022
• what: To providing validated gene program discovery methods (e_g ICA and NMF) the authors introduce the SSN method which the authors demonstrate has superior recovery of known gene ontologies (GO) and enrichment of STRING-curated protein-protein interactions (PPI). The authors propose using the CDI to identify cluster-specific bDEGs within scRNA-seq data. Having demonstrated that the CDI . . .
  

   

  

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