Multi-omics analysis defines highly refractory ras burdened immature subgroup of infant acute lymphoblastic leukemia

HIGHLIGHTS

• who: Tomoya Isobe from the Patients and samples This study comprised , infants (aged andlt have published the Article: Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia, in the Journal: (JOURNAL) of 20/Dec/2021
• what: Nature Communications | 13:4501 This study shows the heterogeneous molecular pathobiology of KMT2A-r infant ALL using a fully unsupervised, integrative multiomics approach.
• how: Since these results indicated that the IRX subtype (IC1-2) is less differentiated towards the B-cell lineage compared to the HOXA subtype (IC3-5) the authors . . .
  

   

  

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