Multi-omics profiling of hypertrophic cardiomyopathy reveals altered mechanisms in mitochondrial dynamics and excitation-contraction coupling

HIGHLIGHTS

• who: Jarrod Moore and collaborators from the Center for Network Systems Biology, Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA have published the article: Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling, in the Journal: (JOURNAL) of 21/01/2023
• what: For this analysis, the authors accurately quantified select glycolytic/citric_acid_cycle intermediates using 13 C stable-isotope glucose tracer to determine whether unlabeled glutamate was supplementing the citric_acid_cycle . In contrast, the authors provide direct phosphorylation level regulation of this pathway, which helps explain those . . .
  

   

  

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