Multiancestry exome sequencing reveals inhbe mutations associated with favorable fat distribution and protection from diabetes

HIGHLIGHTS

• who: Parsa Akbari from the (UNIVERSITY) have published the research work: Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes, in the Journal: (JOURNAL) of 28/07/2022
• what: The authors show 6-fold larger effect for fat-distribution associated rare coding variants compared with fine-mapped common alleles, enrichment for genes expressed in adipose_tissue and causal genes for partial lipodystrophies, and evidence of sex-dimorphism. By using genomic data in conjunction with "gold-standard" liver MRI imaging and histopathology phenotypes, the study shows the profound impact of adipose . . .
  

   

  

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