Multibacmam bimolecular fluorescence complementation (bifc) tool-kit identifies new small-molecule inhibitors of the cdk5-p25 protein-protein interaction (ppi)

HIGHLIGHTS

• who: Itxaso Bellamp#x000F3 et al. from the (UNIVERSITY) have published the Article: MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI), in the Journal: (JOURNAL) of 27/Nov/2017
• what: Based on these results, the authors selected the construct with split Venus fused to the N-termini of CDK5D144N and p25 for the experiments described below.
• how: The authors evaluated the tool -kit with the known inhibitor p5T and the authors established a mini-screen to identify compounds that modulate this . . .
  

   

  

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