Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its dna-binding and ligand-binding domains

HIGHLIGHTS

• who: Wei Huang from the Center forReserve University have published the paper: Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• how: To investigate how the different domains within the hERα interact with each other the authors conducted multiple highly complementary in-solution biophysical studies using a recombinant active form of the hERα protein. The goodness of fit of each structural candidate against the experimental SAXS and footprinting data was evaluated via two scoring functions χ2 and φ2.

 

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