Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

HIGHLIGHTS

  • who: Ying Zhang from the All animal studies in this research were approved by the Institutional Animal Care and Use Committee at the University of Wisconsin, Madison (protocol:, ) have published the Article: Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade, in the Journal: (JOURNAL) of 19/Oct/2021
  • what: To overcome this, the authors develop a multifunctional nanoparticle composed of polylysine, iron oxide, and CpG (PIC) to increase tumor antigen presentation, increase the ratio of M1:M2 tumor-associated macrophages, and enhance stimulation of a . . .

     

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