HIGHLIGHTS
SUMMARY
The CAFs within the TME were identified by IHC using a panel of six antibodies (FAP, SMAa, FSP1, CD36, PDGFRa, and PDGFRb) as well as gene_expression profiling using TempO-sequence analysis. There was a significant positive correlation between increasing tissue stiffness in tumor stroma and SMAa and PDGFRb gene_expression in the fibromuscular stroma (p and amp;lt; 0.001). CAF heterogeneity was explored using immunohistochemistry and gene_expression. Representative blocks of the tumor were selected for subsequent immunohistochemical and gene_expression studies. The authors also calculated upgrading/downgrading of GS from biopsies to radical surgery in . . .
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