Multiomics profiling of dna methylation, microrna, and mrna in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism

HIGHLIGHTS

• What: Methods By applying multiomics mRNA microRNA (miRNA) and DNA methylation platforms in biopsies from 20 twin pairs for T2D the authors aimed to delineate the epigenetic and transcriptional machinery underlying non-genetic muscle insulin resistance in T2D. Together the authors show that T2D is associated with non- and epigenetically determined differential tran‑ scriptional regulation of pathways regulating skeletal muscle metabolism and contraction. The study was carried out in accordance with the Declaration of Helsinki. also analyzed by gene set enrichment analysis (GSEA) using reactome pathways (fgsea and reactome.db packages, Bioconductor) . The authors performed an integrative . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.