Multiple-allele mhc class ii epitope engineering by a molecular dynamics-based evolution protocol

HIGHLIGHTS

• who: Rodrigo Ochoa from the Biophysics of Tropical Diseases, Max Planck Tandem Group, University of Antioquia UdeA, Medellin, Colombia have published the paper: Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol, in the Journal: (JOURNAL)
• what: The authors developed an in silico design approach to address these challenges, and engineer peptides with improved experimental binding affinity toward many MHC II alleles simultaneously. Analysis, the authors selected four positions, three in the core and one in the flanking region (stars in Figure 3B), to mutate during the design protocol. The . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.