Multiple extracellular loop domains contribute critical determinants for agonist binding and activation of the secretin receptor*

HIGHLIGHTS

• who: Martin H. Holtmann from the (UNIVERSITY) have published the paper: Multiple Extracellular Loop Domains Contribute Critical Determinants for Agonist Binding and Activation of the Secretin Receptor*, in the Journal: (JOURNAL)
• what: This work explores the secretin receptor determinants that are critical for ligand binding and the resultant stimulation of signaling cascades.
• how: For this a protocol based on the DEAE-dextran method was used including dimethyl sulfoxide shock and treatment with 0.1 mM chloroquine diphosphate .
• future: This represents a direct extension of the previous work which also utilized secretin . . .
  

   

  

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