Multiple host barriers restrict poliovirus trafficking in mice

HIGHLIGHTS

• who: Mice et al. from the Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America have published the article: Multiple Host Barriers Restrict Poliovirus Trafficking in Mice, in the Journal: (JOURNAL)
• what: The authors propose that multiple host barriers and the resulting limited poliovirus population diversity may help explain the rare occurrence of viral CNS invasion and paralytic poliomyelitis. The authors propose that entry into the brain is difficult, but once in the brain, founder viruses undergo robust replication. Because interferons (IFN) play an important role in controlling viral . . .
  

   

  

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