Multiple myeloma exemplifies a model of cancer based on tissue disruption as the initiator event

HIGHLIGHTS

  • who: Jean-Pascal Capp from the CNRS, INRA, INSA Toulouse, University of Toulouse, Toulouse, France, Faculty of Medecine have published the research work: Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event, in the Journal: (JOURNAL)
  • what: This study has confirmed that the transition from MGUS to SMM to overt MM was associated to both an increase of the LI and a decrease of the apoptotic index. The authors propose that CD45 heterogeneity originates from initial disruption of bone-PC interactions, and that a selective process against CD45 expression . . .

     

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