HIGHLIGHTS
SUMMARY
There exist a number of classical methods for the synthesis of substituted pyrazines via homocondensation of α-aminoketones and α-aminoaldehydes, co-condensation of ethylenediamines with 1,2-diketones, the reaction of 2-nitrooxiranes with ammonia, the reaction of aryl-substituted α-hydroxyketones with ammonium acetate in acetic acid, the cyclodimerization reactions of azirines, as well as cyclizations of N,N`-dibenzylidene derivatives and others. Among this variety of reactions, the synthesis of substituted pyrazines from nitriles does not stand out in either the number of known examples or in product yield. The authors recently reported a . . .
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