Multiple pkd and piezo gene family members are required for atrioventricular valve formation

HIGHLIGHTS

• who: Thomas Juan from the (UNIVERSITY) have published the article: Multiple pkd and piezo gene family members are required for atrioventricular valve formation, in the Journal: (JOURNAL)
• what: The authors show that Pkd1a, together with Pkd2, Pkd1l1, and Piezo2a, promotes AV valve elongation and cardiac morphogenesis. The authors show that these sorted double and triple pkd mutants display a wild-type-like cardiac chamber size (Fig 2a-d and Fig S2h, i), and beating frequency (Fig S2j) at 78 hpf. For the experiments with piezo1, piezo2a, pkd1l1, camk2g1, and camk2g2 mutants, maternal zygotic mutants from . . .
  

   

  

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