Multiplexed tat-targeting crispr-cas9 protects t cells from acute hiv-1 infection with inhibition of viral escape

HIGHLIGHTS

• who: Youdiil Ophinni et al. from the Division of Molecular Medicine and Medical Genetics, Department of Pathology, Kobe University Graduate have published the paper: Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape, in the Journal: (JOURNAL)
• what: The presence of replication-competent integrated provirus, even under antiretroviral therapy (ART) suppression, is the main reason for recrudescent viremia in HIV-1-infected individuals. The authors propose a multiplexed CRISPR-Cas9 attack of three and six gRNAs, all concentrated at HIV-1 regulatory_genes as a means to . . .
  

   

  

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