Multivalent pyrrolidine iminosugars: synthesis andbiological relevance

HIGHLIGHTS

• who: Yali Wang and colleagues from the College of Pharmacy, North China University of Science and Technology, Tangshan, China have published the article: Multivalent Pyrrolidine Iminosugars: Synthesis andBiological Relevance, in the Journal: Molecules 2022, 5420 of /2022/
• what: The last decade has witnessed the rapid development of multivalent effects in glycosidase inhibition and drug discovery.
• how: Showed that the nonavalent pyrrolidine iminosugar 83 exhibited impressive inResults showed that the nonavalent pyrrolidine iminosugar 83 exhibited impres hibition of N-acetylgalactosamine-6-sulfatase (GALNS). Showed that all the newly synthesized compounds displayed high AFU inhibition . . .
  

   

  

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