HIGHLIGHTS
- who: Nicolas J. Wheeler from the University of Wisconsin-Eau Claire, Eau Claire, WI, USA have published the research: Multivariate chemogenomic screening prioritizes new macrofilaricidal leads, in the Journal: (JOURNAL) of 27/07/2022
- what: The authors show that tiered phenotyping greatly increases the efficiency of hit discovery in macrofilaricide screens and more thoroughly characterizes the bioactivity of lead compounds resulting in the identification of more than a dozen compounds with submicromolar potency against filarial adults. The authors presume that the later time point (36 hpt vs 12 hpt) of the viability assay is the . . .
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