Murine breast cancers disorganize the liver transcriptome in a zonated manner

HIGHLIGHTS

  • who: Alexis Vandenbon from the Institut Kyoto University, Kyoto, Japan have published the Article: Murine breast cancers disorganize the liver transcriptome in a zonated manner, in the Journal: (JOURNAL) of 12/09/2022
  • what: Combining spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) the authors characterize the livers of breast cancer-bearing animals at the spatial and singlecell resolution finding that murine breast cancers disrupt liver zonation. The authors demonstrate uniquely altered patterns of zonated gene expression in the liver. No blinding was done in the experiments described in this study.
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