Muscarinic modulation of sk2-type k+ channels promotes intrinsic plasticity in l2/3 pyramidal neurons of the mouse primary somatosensory cortex

HIGHLIGHTS

• who: Significance Statement et al. from the Department of Neurobiology, University of Chicago, Chicago, IL , have published the paper: Muscarinic Modulation of SK2-Type K+ Channels Promotes Intrinsic Plasticity in L2/3 Pyramidal Neurons of the Mouse Primary Somatosensory Cortex, in the Journal: (JOURNAL)
• what: The authors investigate whether mAChR activation can drive SK channel-dependent intrinsic plasticity in L2/3 cortical pyramidal neurons. Using mice with an inactivation of CaMKII (T305D mice) the authors show that intrinsic plasticity does not require CaMKII. The authors demonstrate that repeated injection of depolarizing pulses in the presence . . .
  

   

  

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