Mutagenesis and structural modeling implicate rme-8 iwn domains as conformational control points

HIGHLIGHTS

• who: Anne Norris and colleagues from the Department of Molecular Biology and Biochemistry Rutgers University, Piscataway, New Jersey, United have published the Article: Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points, in the Journal: (JOURNAL) of October/24,/2022
• what: Combining AlphaFold structural predictions with in vivo mutation analysis of RME-8 the authors propose a model whereby SNX-1 and the IWN domains control the conformation of RME-8 and hence the productive exposure of the DNAJ domain. The authors propose that the activation of RME-8 is cyclical . . .
  

   

  

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