HIGHLIGHTS
- who: Mariana L. Oliveira from the (UNIVERSITY) have published the paper: Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia, in the Journal: (JOURNAL) of 17/05/2022
- what: 1534 Here, the authors show that IL7R gain-of-function alone is sufficient to trigger T-cell leukemogenesis in zebrafish, a process that involves increased IL-7R-mediated signaling as well as transcriptional activation of MYC. The authors showed that IL7R mutation collaborates with Myc in accelerating T-ALL onset and decreasing apoptosis of leukemia cells.
SUMMARY
Although there . . .
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