HIGHLIGHTS
SUMMARY
To identify more interpretable ICI response biomarkers based on tumor mutations, the authors train classifiers using mutations within distinct biological processes. CTLA-4 is a T-cell surface protein which binds to B7-1 and B7-2 expressed by antigen-presenting cells (APC)12, resulting in suppression of immune_response by the T_cells. To evaluate whether mutated genes within biological processes can predict ICI treatment responses in metastatic melanoma, the authors obtained training and validation mutation and clinical datasets from metastatic melanoma patients treated with anti-PD1. To identify subsets of genes within distinct biological . . .
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