Mutation and selection of prions

HIGHLIGHTS

  • who: Pearls, and Charles, Weissmann from the Departmentdisease afflicting cervids in , states of the United StatesWashington University have published the paper: Mutation and Selection of Prions, in the Journal: (JOURNAL) of March/29,/2012

SUMMARY

    Published Prion Strains Funding: This study was supported by grants from the National Institutes of Health (1RO1NSO59543, 1R01NSO67214) and the Alafi Family Foundation. Propagation, mutation, and selection of prions in cultured cells. Brain-adapted 22L prions are resistant to swainsonine treatment when assayed on PK1 cells and are able to infect R33 cells (R33 competent). When propagated in . . .

     

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