Mutation in glutamate transporter homologue glttk provides insights into pathologic mechanism of episodic ataxia 6

HIGHLIGHTS

• who: Emanuela Colucci from the (UNIVERSITY) have published the Article: Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6, in the Journal: (JOURNAL) of 22/07/2022
• what: The authors show that also in GltTk the P208R mutation leads to reduced aspartate transport activity and increased anion conductance, however a cryo-EM structure reveals that the kink is preserved. The authors investigated the functional and structural effects of the point mutation from proline to arginine at position 208 on the archaeal homologue GltTk. To EAAT1, EAAT2 and GltPh, this . . .
  

   

  

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