HIGHLIGHTS
- who: Press et al. from the of Transcription Laboratory, London WC A LY, United Kingdom have published the Article: Mutation of cancer driver MLL2 results in transcription stress and genome instability, in the Journal: (JOURNAL)
- what: The authors report that MLL2 mutation indeed gives rise to significant genomic instability in areas overlapping with early replicating fragile sites (ERFSs). The authors show that MLL2 plays an important role in maintaining genomic stability, providing a new conceptual basis for understanding its widespread role in tumorigenesis. Using a variety of cell biological and genome-wide assays, the authors . . .
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