Mutation of foxl1 results in reduced cartilage markers in zebrafish model of otosclerosis

HIGHLIGHTS

  • who: Genes and collaborators from the Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland have published the research: Mutation of foxl1 Results in Reduced Cartilage Markers in Zebrafish Model of Otosclerosis, in the Journal: Genes 2022, 1107 of /2022/
  • what: The authors demonstrate that foxl1 regulates the expression of collagen such as collagen type 1 alpha 1a and collagen type 11 alpha 2 and results in delay in jawbone mineralization while the axial skeleton remains unchanged. foxl1 may also act with other forkhead such as foxc1a as loss of foxl1 in foxc1a . . .

     

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