Mutation of the glycine residue preceding the sixth tyrosine of the lat adaptor severely alters t cell development and activation

HIGHLIGHTS

• who: Mikel M. Arbulo-Echevarria et al. from the University of Siena, Italy have published the research: Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation, in the Journal: (JOURNAL)
• future: The preliminary results suggest that favoring phosphorylation of LAT-Y136 increases the autoimmune potential of T_cells although more work is needed to identify the molecular mechanisms involved on that phenomenon. Studies are needed to identify the intracellular signals involved in the differential phenotype of peripheral CD4+ and CD8+ lymphocytes.

SUMMARY

 



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