Mutation of the salt bridge-forming residues in the etv6-sam domain interface blocks etv6-ntrk3-induced cellular transformation*

HIGHLIGHTS

• who: Naniye Cetinbas from the (UNIVERSITY) have published the Article: Mutation of the Salt Bridge-forming Residues in the ETV6-SAM Domain Interface Blocks ETV6-NTRK3-induced Cellular Transformation*, in the Journal: (JOURNAL) of September/27,/2013
• what: The authors demonstrate the importance of electrostatic interactions within the SAM domain polymer interface for EN-mediated cellular transformation. The authors show that mutation of the Lys-99, which is involved in a salt bridge with Asp-101 between neighboring SAM domains, reduces polymerization and formation of high molecular mass complexes and, in addition, blocks transformation activity . . .
  

   

  

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