Mutation signature analysis identifies increased mutation caused by tobacco smoke associated dna adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx

HIGHLIGHTS

• who: Andrew P. South from the DepartmentJefferson University, Philadelphia, PA, USA have published the paper: Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx, in the Journal: Scientific Reports Scientific Reports
• what: The authors show here that the increased mutation burden in larynx SCC noted by others is a direct result of tobacco smoke-associated signature 4 mutation load (Fig 1, Supplementary Figs S2 and S5). Whilst the analysis presented in the study is descriptive in nature and the authors . . .
  

   

  

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