Mutational analyses of the cysteine-rich domain of yvh1, a protein required for translational competency in yeast

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  • who: Hannah Zang and collaborators from the Duke University School of Medicine, Durham, NC, USA have published the Article: Mutational Analyses of the Cysteine-Rich Domain of Yvh1, a Protein Required for Translational Competency in Yeast, in the Journal: (JOURNAL) of 25/05/2022
  • what: The authors report an unbiased genetic screen to isolate variants that fail to displace from pre-60S ribosomes. The __NEWPAGE__Biology 2022 11 1246 2 of 21 further characterization of one LOF variant Yvh1F283L establishes it as an expression-dependent dominant-negative variant capable of interfering with endogenous function and the . . .

     

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