Myc-mediated resistance to trametinib and hcq in pdac is overcome by cdk4/6 and lysosomal inhibition

HIGHLIGHTS

• who: Kajsa Affolter et al. from the The overall research objective was to determine whether P/CQ overcomes c-MYC-mediated resistance to T/CQ in PDACAfter observing the correlation between c-MYC expression and T/CQ resistance, the first objective was to determine whether c-MYC alone promotes T/HCQ resistance. The second objective was to identify how c-MYC mediates resistance and whether P/CQ overcomes T/CQ resistance. To accomplish these objectives, the following methods were used: xenograft mouse studies, flow cytometry, proliferation assays, IHC staining, histopathology analysis, immunoblotting, electron microscopy, and fluorescence microscopy . . .
  

   

  

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