Myc sensitises cells to apoptosis by driving energetic demand

HIGHLIGHTS

• who: Joy Edwards-Hicks from the Xenograft models In all, u00d7 , Raji cells were injected subcutaneously into the right flank of, to, week-old male NOD-SCID IL Ru03b3-null (NSG) miceAfter , days, the animals were treated daily with intraperitoneal injections of either vehicle control or , mg/kg CPI-613. Tumour weight and engraftment were analysed when animals were euthanized because burden became large (approaching, ., cm in any dimension-no mice exceeded these limits) or when animals showed signs of poor health. All mice were maintained in a standard SPF facility (, light/, dark cycle, u00b0C with, % humidity . . .
  

   

  

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