HIGHLIGHTS
- who: Sofia Zanotti from the LaboratoryUniversity of USA have published the Article: MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells, in the Journal: Scientific Reports Scientific Reports
- what: Taken together, the authors propose that unscheduled MYCN activation causes ribosome biogenesis and nucleolar stress in G2-phase, pre-priming cells for faltering in subsequent G1 and slowing down cell proliferation. The authors propose that ribosome biogenesis and the consequent nucleolar stress drives cells into what the authors propose to represent a pre-senescent state.
SUMMARY
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