HIGHLIGHTS
- who: Grace Mugumbate et al. from the School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom, Diseases of have published the article: Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation, in the Journal: PLOS ONE | DOI:10.1371/journal.pone [0121492]. March 23, 2015 of /1371/
- what: There are no drugs presently in clinical use that target this enzyme for Mtb, therefore this work provides experimentally confirmed ligands for mycobacterial DHFR, which will serve as starting points for further hit-to-lead optimisation. The efficiency of the model was indicated . . .
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