Mycobacterium tuberculosis induces irg1 in murine macrophages by a pathway involving both tlr-2 and sting/ifnar signaling and requiring bacterial phagocytosis

HIGHLIGHTS

• who: Caio C. B. Bomfim from the Wu00fcrzburg, Germany Kanazawa University, Japan have published the article: Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis, in the Journal: (JOURNAL)
• what: The authors have examined in detail the pathways responsible for the innate induction of Irg1 by Mtb in murine BMDM. The authors demonstrate that Mtb triggers Irg1 expression directly through TLR2-/MyD88/NF-kB signaling and indirectly through STING dependent Type I IFN synthesis.
• how: All studies were conducted in . . .
  

   

  

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