HIGHLIGHTS
- who: Yinuo Li from the Department of Pathology, Feinberg School of Medicine, Northwestern University, East Huron Street, Feinberg, ‑334, Chicago, IL, USA have published the research work: Myometrial oxidative stress drives MED12 mutations in leiomyoma, in the Journal: (JOURNAL)
- what: Altogether, the study demonstrates for the first time, a clear connection between increased myometrial ROS and MED12 mutations that may underlie leiomyoma development.
- how: The authors proposed in this study that increased ROS promotes 8-OHdG modifications which cause misrepair due to transversions of G nucleotide.
- future: Research is needed to . . .
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