Myosin heavy chain converter domain mutations drive early-stage changes in extracellular matrix dynamics in hypertrophic cardiomyopathy

HIGHLIGHTS

• who: Myosin Heavy Chain Converter et al. from the Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, Department of Pediatrics have published the research work: Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy, in the Journal: (JOURNAL)
• what: The authors focus the efforts on dual mutations in MYH7 and MYH6. Rodent models are of limited value for this study since mice predominantly express MYH6 in the heart as compared to MYH7 in the human heart with significantly different cardiac electrophysiological properties relative to . . .
  

   

  

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