Myosin vi-dependent actin cages encapsulate parkin-positive damaged mitochondria

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  • who: Antonina J. Kruppa from the Cambridge Institute University of Wellcome Trust/MRC Building, Hills Road, Cambridge, XY, UK have published the Article: Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria, in the Journal: (JOURNAL) of February/26,/2018
  • what: The authors demonstrate that MYO6 is recruited via its ubiquitin-binding domain and independently from the autophagy receptors to damaged mitochondria by a Parkin-dependent mechanism. Taken together, the authors show that endogenous as well as ectopically expressed MYO6 translocate to the OMM upon mitochondrial stress in a Parkin-dependent manner and also . . .

     

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